So Venom has an edge in that he doesn't need to breathe, but that shouldn't be an issue for Static who can keep Venom away from him with forcefields. Even if statics breather gets trashed he'll just fix it, so it shouldn't end up being a game changer even if Venom somehow reaches him.
What will be a game changer is Static's ability to create heat. He can mimic blowtorches powerful enough to melt through thick steel quickly.
And while I think this is a bit of an edge case, Static's control of his powers could even allow him to separate the symbiote from its host.
It's not a particular weakness, but from what I can gather it does hurt if powerful enough. Static does generate powerful electric shocks, and electricity does generate heat, plus a lightning bolt can pretty easily light some trees on fire.